Cómo Quedar Embarazada (Spanish Edition)

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Rumack CM, et al. The first trimester. In: Diagnostic Ultrasound. Walls RM, et al. Acute complications of pregnancy.

Berkowitz RS, et al. Hydatidiform mole: Epidemiology, clinical features, and diagnosis. Gockley AA, et al. The effect of adolescence and advanced maternal age on the incidence of complete and partial molar pregnancy. Gynecologic Oncology.

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What is gestational trophoblastic disease? American Cancer Society. Hydatidiform mole: Management. Diagnosis and treatment of gestational trophoblastic disease. Rockville, Md. Frequently asked questions. Special procedures FAQ Dilation and curettage. American College of Obstetricians and Gynecologists. Wick MJ expert opinion. Mayo Clinic, Rochester, Minn. Eleven trials included women with a 'good prognosis' i. Two of 15 studies compared vasodilator plus another agent versus placebo or no treatment Aleyasin ; Kim Three of 15 studies reported live births Aleyasin ; Farzi ; Ohl Four of 15 studies reported side effects Fahmy ; Mahran ; Ohl ; Shaker We did not include in analyses studies reporting biochemical pregnancy.

Four of 15 studies reported other adverse events Aleyasin ; Alieva ; Farzi ; Ohl No study provided data on the number of participants with thickened endometrium. Only two studies mentioned that all women had a thin endometrium before treatment Das ; Kim However, five studies reported a mean difference in thickened endometrium Abdel ; Azmy ; Das ; Magdi Ammar ; Mahran Four of 11 studies did not include participants of interest for this review Alborzi ; Balasch ; Creus ; Kamencic One of 11 studies did not include comparisons of interest for this review Rosen One of 11 studies did not include outcomes of interest for this review Malinova In addition, two studies are awaiting classification Casper ; Penzias , and one study is ongoing NCT In Figure 2 and Figure 3 , we have shown and summarised the judgements of review authors regarding each risk of bias item for each included study.

Five studies had low risk of selection bias related to sequence generation Abdel ; Aleyasin ; Dehghani Firouzabadi ; Magdi Ammar ; Ohl Five studies had low risk of bias related to allocation concealment Abdel ; Aleyasin ; Fahmy ; Mahran ; Ohl Five of 15 studies had low risk of performance bias Abdel ; Aleyasin ; Farzi ; Ohl ; Shaker Three studies did not provide a description of blinding Alieva ; Magdi Ammar ; Mostafa Seven of 15 studies did not mention blinding, and we judged them as having unclear risk of detection bias Alieva ; Azmy ; Fahmy ; Magdi Ammar ; Mahran ; Mostafa ; Shaker Blinding was not considered as likely to influence the outcome of live birth or clinical pregnancy.

The same was not true for adverse events, for which lack of blinding could potentially affect findings. These studies had unclear risk of attrition bias. One of 15 studies was at high risk of attrition bias Magdi Ammar Ten of 15 studies reported outcomes that were clearly prespecified in the methods section, and we classified them as having low risk of selective reporting bias Abdel ; Aleyasin ; Azmy ; Dehghani Firouzabadi ; Fahmy ; Farzi ; Kim ; Magdi Ammar ; Ohl ; Shaker Four of these studies reported primary outcomes Aleyasin ; Farzi ; Ohl ; Shaker : three studies reported live birth Aleyasin ; Farzi ; Ohl , and four reported adverse effects Fahmy ; Mahran ; Ohl ; Shaker However, the protocol was available for only one study Dehghani Firouzabadi In addition, four studies reported baseline comparability regarding type of infertility, cause of infertility, and body mass index.

We classified these studies as having low risk of bias. We identified no other potential sources of bias. However, three studies did not report baseline features, and we judged them to have unclear risk of detection bias Alieva ; Azmy ; Mostafa See: Summary of findings for the main comparison Vasodilator compared to placebo or no treatment for women undergoing fertility treatment.

Analysis 1. Vasodilators given alone or with another agent probably make little or no difference in rates of "live birth or ongoing pregnancy" compared with placebo or no treatment RR 1. We stratified the analysis by type of vasodilator. Forest plot of comparison: 1 Vasodilator vs placebo or no treatment, outcome: 1. Four studies reported the number of vasodilator side effects by group.

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The vasodilator group most commonly reported the following adverse events AEs : hypotension, headache, tachycardia, dizziness, hot flushes, nervousness, insomnia, constipation, and a feeling of weakness. Vasodilators alone or with another agent probably increase side effects compared with placebo or no treatment RR 2. Two studies reported specific vasodilator side effects.

One compared sildenafil versus placebo Fahmy , and another isosorbide mononitrate ISMN versus no treatment Mahran Vasodilators may increase headache RR 4. Evidence was insufficient to show whether groups had differences in hypotension RR 1.

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Fifteen studies reported clinical pregnancy. Two studies did not report the method used to diagnose pregnancy Alieva ; Shaker We included them in the analyses and noted this limitation in the footnotes. Alieva and Dehghani Firouzabadi compared sildenafil versus no treatment or placebo. Kim compared sildenafil plus oestrogen versus no treatment. Magdi Ammar compared tadalafil versus placebo.

Vasodilators alone or with another agent may slightly improve clinical pregnancy compared with placebo or no treatment RR 1. Five studies reported thickened endometrium. We are uncertain whether vasodilators improved thickened endometrium, as we have assessed the quality of the evidence as very low. We downgraded the quality of evidence because of high risk of bias and inconsistency Analysis 1.

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Ohl compared glyceryl trinitrate GTN versus placebo. Abdel compared isosorbide mononitrate IMN versus placebo. Vasodilators probably make little or no difference in rates of multiple gestation or birth compared with placebo or no treatment RR 1. Farzi and Ohl compared glyceryl trinitrate GTN versus placebo. Alieva compared sildenafil versus no treatment. In one study, the miscarriage rate in the control group looked unusually high Alieva So, we analysed only three studies Aleyasin ; Farzi ; Ohl Vasodilators probably make little or no difference in ectopic pregnancy rates compared with placebo or no treatment RR 1.

We did not conduct some analyses initially proposed as stratified because we found no suitable studies. As none of the included studies provided data on the number of women with endometrium measured as greater or less than 8 mm, we could not perform planned subgroup analyses. Only two studies mentioned that all women had a thin endometrium before interventions were provided Das ; Kim Todos los estudios informaron el embarazo como un resultado.

Cinco estudios fueron controlados con placebo, pero no especificaron el uso de cegamiento. Otros estudios no se cegaron o bien olvidaron mencionar el cegamiento. El riesgo de informe selectivo fue incierto en algunos estudios. No se encontraron otras revisiones en pacientes sometidas a tratamiento de fertilidad asistida con vasodilatadores. Risk of bias graph: review authors' judgements about each risk of bias item presented as percentages across all included studies.

Risk of bias summary: review authors' judgements about each risk of bias item for each included study. Comparison 1 Vasodilator vs placebo or no treatment, Outcome 3 Specific vasodilator side effects. All sections are selected by default , please select the sections you do not wish to print or use the select or deselect all button to add or remove sections. The data available are protected by copyright and may only be used in accordance with the Terms and Conditions.

Downloaded data can only be viewed using Review Manager software. Please note that: data are only available for Cochrane Reviews that contain one or more forest plots; and data in the downloaded RevMan file are editable and therefore the review data can be amended without warning. I agree to these terms and conditions Download data. If you have a Wiley Online Library institutional username and password, enter them here. Skip to Content Cookies. I accept. Browse Advanced search. Content Language Selection. Your language preference is set to Spanish. Where translations are available, article sections will display in this language.

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Objetivos Evaluar la efectividad y la seguridad de los vasodilatadores en pacientes que reciben tratamiento de fertilidad. Resultados principales Se incluyeron 15 estudios con un total de mujeres. Conclusiones de los autores No hubo suficiente evidencia para demostrar si los vasodilatadores aumentan la tasa de nacidos vivos en las pacientes sometidas a tratamiento de fertilidad. Resultados clave Solamente tres de los estudios incluidos informaron sobre las tasas de nacidos vivos.


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Calidad de la evidencia La evidencia es de baja a moderada calidad. Summary of findings. Open in table viewer Summary of findings for the main comparison. Vasodilator compared to placebo or no treatment for women undergoing fertility treatment. Open in figure viewer Download as PowerPoint Figure 4. Open in figure viewer Download as PowerPoint Figure 5. Open in figure viewer Download as PowerPoint Figure 6. Figures and Tables -. Flow of information through different phases of the systematic review.